BDBM50248608 CHEMBL4063358

SMILES: CSc1sc(C(N)=O)c2CCc3cnn(C)c3-c12

InChI Key: InChIKey=RXQSXUFJBOKCAT-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248608   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CDK19/Cyclin C (Homo sapiens (Human))	BDBM50248608 (CHEMBL4063358) Show SMILES CSc1sc(C(N)=O)c2CCc3cnn(C)c3-c12 Show InChI InChI=1S/C12H13N3OS2/c1-15-9-6(5-14-15)3-4-7-8(9)12(17-2)18-10(7)11(13)16/h5H,3-4H2,1-2H3,(H2,13,16)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248608 (CHEMBL4063358) Show SMILES CSc1sc(C(N)=O)c2CCc3cnn(C)c3-c12 Show InChI InChI=1S/C12H13N3OS2/c1-15-9-6(5-14-15)3-4-7-8(9)12(17-2)18-10(7)11(13)16/h5H,3-4H2,1-2H3,(H2,13,16)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50248608 (CHEMBL4063358) Show SMILES CSc1sc(C(N)=O)c2CCc3cnn(C)c3-c12 Show InChI InChI=1S/C12H13N3OS2/c1-15-9-6(5-14-15)3-4-7-8(9)12(17-2)18-10(7)11(13)16/h5H,3-4H2,1-2H3,(H2,13,16)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair