null
SMILES: COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
InChI Key: InChIKey=NENJFZKQHYXRDQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human)) | BDBM50248614 (CHEMBL4066819) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.990 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay | Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 9 (Homo sapiens (Human)) | BDBM50248614 (CHEMBL4066819) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of CDK9 (unknown origin) | Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 19 (Homo sapiens (Human)) | BDBM50248614 (CHEMBL4066819) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Binding affinity to partial length wild-type human CDK19 (M1 to N360 residues) expressed in bacterial expression system by KINOMEscan assay | Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50248614 (CHEMBL4066819) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Binding affinity to partial length wild-type human CDK8 (M1 to T360residues) expressed in bacterial expression system by kinome scan assay | Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase haspin (Homo sapiens (Human)) | BDBM50248614 (CHEMBL4066819) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Binding affinity to partial length wild-type human HASPIN (I452 to K798 residues) expressed in bacterial expression system by kinome scan assay | Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homeodomain-interacting protein kinase 1 (Homo sapiens (Human)) | BDBM50248614 (CHEMBL4066819) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Binding affinity to partial length human HIPK1 (M146 to I555 residues) expressed in mammalian expression system by kinome scan assay | Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 3 (Homo sapiens (Human)) | BDBM50248614 (CHEMBL4066819) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Binding affinity to partial length wild-type human EPHA3 (D604 to K889 residues) expressed in bacterial expression system by kinome scan assay | Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C (Homo sapiens (Human)) | BDBM50248614 (CHEMBL4066819) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay | Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50248614 (CHEMBL4066819) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method | Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Homo sapiens (Human)) | BDBM50248614 (CHEMBL4066819) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Binding affinity to full length human DYRK1B (M1 to S629 residues) expressed in bacterial expression system by kinome scan assay | Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase 19 (Homo sapiens (Human)) | BDBM50248614 (CHEMBL4066819) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Binding affinity to partial length wild-type human YSK4 (T1019 to H1328 residues) expressed in bacterial expression system by kinome scan assay | Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H | |||||||||||
More data for this Ligand-Target Pair |