BDBM50248633 CHEMBL4083552

SMILES: NC(=O)c1sc(Oc2ccccc2)c-2c1CCc1cnsc-21

InChI Key: InChIKey=XALHKECHUOZBNB-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248633   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CDK19/Cyclin C (Homo sapiens (Human))	BDBM50248633 (CHEMBL4083552) Show SMILES NC(=O)c1sc(Oc2ccccc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C16H12N2O2S2/c17-15(19)14-11-7-6-9-8-18-22-13(9)12(11)16(21-14)20-10-4-2-1-3-5-10/h1-5,8H,6-7H2,(H2,17,19)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248633 (CHEMBL4083552) Show SMILES NC(=O)c1sc(Oc2ccccc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C16H12N2O2S2/c17-15(19)14-11-7-6-9-8-18-22-13(9)12(11)16(21-14)20-10-4-2-1-3-5-10/h1-5,8H,6-7H2,(H2,17,19)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50248633 (CHEMBL4083552) Show SMILES NC(=O)c1sc(Oc2ccccc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C16H12N2O2S2/c17-15(19)14-11-7-6-9-8-18-22-13(9)12(11)16(21-14)20-10-4-2-1-3-5-10/h1-5,8H,6-7H2,(H2,17,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.770	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair