null

SMILES: NC(=O)c1sc(Oc2ccc(N)nc2)c-2c1CCc1cnsc-21

InChI Key: InChIKey=MIRNBYWEECOSRO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248640   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248640 (CHEMBL4074204) Show SMILES NC(=O)c1sc(Oc2ccc(N)nc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C15H12N4O2S2/c16-10-4-2-8(6-18-10)21-15-11-9(13(22-15)14(17)20)3-1-7-5-19-23-12(7)11/h2,4-6H,1,3H2,(H2,16,18)(H2,17,20)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248640 (CHEMBL4074204) Show SMILES NC(=O)c1sc(Oc2ccc(N)nc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C15H12N4O2S2/c16-10-4-2-8(6-18-10)21-15-11-9(13(22-15)14(17)20)3-1-7-5-19-23-12(7)11/h2,4-6H,1,3H2,(H2,16,18)(H2,17,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50248640 (CHEMBL4074204) Show SMILES NC(=O)c1sc(Oc2ccc(N)nc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C15H12N4O2S2/c16-10-4-2-8(6-18-10)21-15-11-9(13(22-15)14(17)20)3-1-7-5-19-23-12(7)11/h2,4-6H,1,3H2,(H2,16,18)(H2,17,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.30	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair