null
SMILES: COc1cc2ncnc(Nc3ccc(O)c(Br)c3)c2cc1OC
InChI Key: InChIKey=CBIAKDAYHRWZCU-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM50248764 (2-bromo-4-(6,7-dimethoxyquinazolin-4-ylamino)pheno...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Researchand Development Curated by ChEMBL | Assay Description Inhibition of JAK2 | Science 302: 875-878 (2003) Article DOI: 10.1126/science.1087061 BindingDB Entry DOI: 10.7270/Q22Z16FK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM50248764 (2-bromo-4-(6,7-dimethoxyquinazolin-4-ylamino)pheno...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Researchand Development Curated by ChEMBL | Assay Description Inhibition of JAK1 | Science 302: 875-878 (2003) Article DOI: 10.1126/science.1087061 BindingDB Entry DOI: 10.7270/Q22Z16FK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50248764 (2-bromo-4-(6,7-dimethoxyquinazolin-4-ylamino)pheno...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.08E+3 | n/a | n/a | n/a | n/a |
Rheinische Friedrich-Wilhelms-University of Bonn Curated by ChEMBL | Assay Description Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay | Eur J Med Chem 164: 193-213 (2019) Article DOI: 10.1016/j.ejmech.2018.12.019 BindingDB Entry DOI: 10.7270/Q2MK6HCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Broad substrate specificity ATP-binding cassette transporter ABCG2 (Homo sapiens (Human)) | BDBM50248764 (2-bromo-4-(6,7-dimethoxyquinazolin-4-ylamino)pheno...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 189 | n/a | n/a | n/a | n/a |
Rheinische Friedrich-Wilhelms-University of Bonn Curated by ChEMBL | Assay Description Inhibition of ABCG2 (unknown origin) expressed in MDCK2 cells co-expressing BCRP (unknown origin) assessed as potentiation of SN-38-induced cytotoxic... | Eur J Med Chem 164: 193-213 (2019) Article DOI: 10.1016/j.ejmech.2018.12.019 BindingDB Entry DOI: 10.7270/Q2MK6HCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50248764 (2-bromo-4-(6,7-dimethoxyquinazolin-4-ylamino)pheno...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Curated by ChEMBL | Assay Description Inhibition of JAK3 (unknown origin) | J Med Chem 61: 9811-9840 (2018) Article DOI: 10.1021/acs.jmedchem.8b00294 BindingDB Entry DOI: 10.7270/Q2XK8J7N | |||||||||||
More data for this Ligand-Target Pair |