BDBM50249030 CHEMBL3770346
SMILES: COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
InChI Key: InChIKey=CTEGQKDJTBWFHW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Muscarinic acetylcholine receptor M2 and M4 (Homo sapiens (Human)) | BDBM50249030 (CHEMBL3770346) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
IntelliSyn Pharma Curated by ChEMBL | Assay Description Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by ... | Bioorg Med Chem Lett 27: 2239-2258 (2017) Article DOI: 10.1016/j.bmcl.2017.03.084 BindingDB Entry DOI: 10.7270/Q2VT1VJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M4 (Homo sapiens (Human)) | BDBM50249030 (CHEMBL3770346) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
IntelliSyn Pharma Curated by ChEMBL | Assay Description Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins ... | Bioorg Med Chem Lett 27: 2239-2258 (2017) Article DOI: 10.1016/j.bmcl.2017.03.084 BindingDB Entry DOI: 10.7270/Q2VT1VJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M4 (RAT) | BDBM50249030 (CHEMBL3770346) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 225 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mob... | Bioorg Med Chem Lett 27: 4999-5001 (2017) Article DOI: 10.1016/j.bmcl.2017.10.016 BindingDB Entry DOI: 10.7270/Q2SJ1P6M | |||||||||||
More data for this Ligand-Target Pair |