BDBM50249145 CHEMBL474965::N,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide

SMILES: CN(C(=O)C1(C)CC2c3ccccc3C1c1ccccc21)c1nccs1

InChI Key: InChIKey=OODSITSYQDCJCK-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50249145   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50249145 (CHEMBL474965 | N,15-dimethyl-N-(1,3-thiazol-2-yl)t...) Show SMILES CN(C(=O)C1(C)CC2c3ccccc3C1c1ccccc21)c1nccs1 |TLB:5:4:8.13:15.20,12:13:6.4:15.20,16:15:8.13:6.4,THB:2:4:8.13:15.20,(21.32,-32.98,;20.53,-31.65,;18.99,-31.67,;18.2,-30.34,;18.23,-33.01,;16.89,-32.23,;18.74,-33.78,;18.75,-35.97,;16.88,-36.49,;15.53,-37.26,;14.2,-36.49,;14.2,-34.94,;15.53,-34.17,;16.84,-35.09,;18.23,-34.42,;19.77,-35.32,;21.04,-34.58,;22.32,-35.31,;22.32,-36.8,;21.04,-37.54,;19.76,-36.8,;21.29,-30.3,;22.83,-30.12,;23.13,-28.61,;21.79,-27.86,;20.65,-28.9,)| Show InChI InChI=1S/C22H20N2OS/c1-22(20(25)24(2)21-23-11-12-26-21)13-18-14-7-3-5-9-16(14)19(22)17-10-6-4-8-15(17)18/h3-12,18-19H,13H2,1-2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	82.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assay				Bioorg Med Chem Lett 19: 2139-43 (2009) Article DOI: 10.1016/j.bmcl.2009.03.006 BindingDB Entry DOI: 10.7270/Q2XW4KRC
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50249145 (CHEMBL474965 | N,15-dimethyl-N-(1,3-thiazol-2-yl)t...) Show SMILES CN(C(=O)C1(C)CC2c3ccccc3C1c1ccccc21)c1nccs1 |TLB:5:4:8.13:15.20,12:13:6.4:15.20,16:15:8.13:6.4,THB:2:4:8.13:15.20,(21.32,-32.98,;20.53,-31.65,;18.99,-31.67,;18.2,-30.34,;18.23,-33.01,;16.89,-32.23,;18.74,-33.78,;18.75,-35.97,;16.88,-36.49,;15.53,-37.26,;14.2,-36.49,;14.2,-34.94,;15.53,-34.17,;16.84,-35.09,;18.23,-34.42,;19.77,-35.32,;21.04,-34.58,;22.32,-35.31,;22.32,-36.8,;21.04,-37.54,;19.76,-36.8,;21.29,-30.3,;22.83,-30.12,;23.13,-28.61,;21.79,-27.86,;20.65,-28.9,)| Show InChI InChI=1S/C22H20N2OS/c1-22(20(25)24(2)21-23-11-12-26-21)13-18-14-7-3-5-9-16(14)19(22)17-10-6-4-8-15(17)18/h3-12,18-19H,13H2,1-2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.24E+3	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene act...				Bioorg Med Chem Lett 19: 2139-43 (2009) Article DOI: 10.1016/j.bmcl.2009.03.006 BindingDB Entry DOI: 10.7270/Q2XW4KRC
					More data for this Ligand-Target Pair