null

SMILES: CC1(CC2c3ccccc3C1c1ccccc21)C(=O)Nc1nncs1

InChI Key: InChIKey=JPBZIHJMUSXRCT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50249192   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50249192 (15-methyl-N-(1,3,4-thiadiazol-2-yl)tetracyclo[6.6....) Show SMILES CC1(CC2c3ccccc3C1c1ccccc21)C(=O)Nc1nncs1 |TLB:0:1:4.9:11.16,8:9:2.1:11.16,12:11:4.9:2.1,THB:17:1:4.9:11.16,(-6.83,-47.54,;-5.48,-48.31,;-4.97,-49.08,;-4.97,-51.28,;-6.84,-51.8,;-8.18,-52.57,;-9.52,-51.8,;-9.51,-50.25,;-8.19,-49.48,;-6.87,-50.4,;-5.48,-49.73,;-3.95,-50.63,;-2.67,-49.89,;-1.39,-50.62,;-1.39,-52.11,;-2.67,-52.85,;-3.95,-52.11,;-4.73,-46.97,;-5.51,-45.64,;-3.18,-46.96,;-2.43,-45.61,;-.89,-45.43,;-.58,-43.92,;-1.93,-43.16,;-3.06,-44.21,)| Show InChI InChI=1S/C20H17N3OS/c1-20(18(24)22-19-23-21-11-25-19)10-16-12-6-2-4-8-14(12)17(20)15-9-5-3-7-13(15)16/h2-9,11,16-17H,10H2,1H3,(H,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assay				Bioorg Med Chem Lett 19: 2139-43 (2009) Article DOI: 10.1016/j.bmcl.2009.03.006 BindingDB Entry DOI: 10.7270/Q2XW4KRC
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50249192 (15-methyl-N-(1,3,4-thiadiazol-2-yl)tetracyclo[6.6....) Show SMILES CC1(CC2c3ccccc3C1c1ccccc21)C(=O)Nc1nncs1 |TLB:0:1:4.9:11.16,8:9:2.1:11.16,12:11:4.9:2.1,THB:17:1:4.9:11.16,(-6.83,-47.54,;-5.48,-48.31,;-4.97,-49.08,;-4.97,-51.28,;-6.84,-51.8,;-8.18,-52.57,;-9.52,-51.8,;-9.51,-50.25,;-8.19,-49.48,;-6.87,-50.4,;-5.48,-49.73,;-3.95,-50.63,;-2.67,-49.89,;-1.39,-50.62,;-1.39,-52.11,;-2.67,-52.85,;-3.95,-52.11,;-4.73,-46.97,;-5.51,-45.64,;-3.18,-46.96,;-2.43,-45.61,;-.89,-45.43,;-.58,-43.92,;-1.93,-43.16,;-3.06,-44.21,)| Show InChI InChI=1S/C20H17N3OS/c1-20(18(24)22-19-23-21-11-25-19)10-16-12-6-2-4-8-14(12)17(20)15-9-5-3-7-13(15)16/h2-9,11,16-17H,10H2,1H3,(H,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	295	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene act...				Bioorg Med Chem Lett 19: 2139-43 (2009) Article DOI: 10.1016/j.bmcl.2009.03.006 BindingDB Entry DOI: 10.7270/Q2XW4KRC
					More data for this Ligand-Target Pair