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BDBM50249221 5-((2R)-2-aminocyclohexylamino)-7-(3,5-dimethoxyphenylamino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamide::CHEMBL471948

SMILES: COc1cc(Nc2nc(NC3CCCC[C@H]3N)n3ncnc3c2C(N)=O)cc(OC)c1

InChI Key: InChIKey=RVIMFNLCTIXVKN-GICMACPYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50249221   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249221
PNG
(5-((2R)-2-aminocyclohexylamino)-7-(3,5-dimethoxyph...)
Show SMILES COc1cc(Nc2nc(NC3CCCC[C@H]3N)n3ncnc3c2C(N)=O)cc(OC)c1 |r|
Show InChI InChI=1S/C20H26N8O3/c1-30-12-7-11(8-13(9-12)31-2)25-18-16(17(22)29)19-23-10-24-28(19)20(27-18)26-15-6-4-3-5-14(15)21/h7-10,14-15,25H,3-6,21H2,1-2H3,(H2,22,29)(H,26,27)/t14-,15?/m1/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Syk (unknown origin)


Bioorg Med Chem Lett 19: 1944-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.049
BindingDB Entry DOI: 10.7270/Q2WM1D98
More data for this
Ligand-Target Pair