BDBM50249258 CHEMBL475570::N-(2,5-dimethylphenyl)-4-(thiazol-2-yl)pyrimidin-2-amine

SMILES: Cc1ccc(C)c(Nc2nccc(n2)-c2nccs2)c1

InChI Key: InChIKey=WPPTYGSKZRVJSC-UHFFFAOYSA-N

Data: 3 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50249258   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50249258 (CHEMBL475570 | N-(2,5-dimethylphenyl)-4-(thiazol-2...) Show SMILES Cc1ccc(C)c(Nc2nccc(n2)-c2nccs2)c1 Show InChI InChI=1S/C15H14N4S/c1-10-3-4-11(2)13(9-10)19-15-17-6-5-12(18-15)14-16-7-8-20-14/h3-9H,1-2H3,(H,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	153	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of SRC (unknown origin)				Bioorg Med Chem Lett 18: 6231-5 (2008) Article DOI: 10.1016/j.bmcl.2008.09.106 BindingDB Entry DOI: 10.7270/Q25Q4VZT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50249258 (CHEMBL475570 | N-(2,5-dimethylphenyl)-4-(thiazol-2...) Show SMILES Cc1ccc(C)c(Nc2nccc(n2)-c2nccs2)c1 Show InChI InChI=1S/C15H14N4S/c1-10-3-4-11(2)13(9-10)19-15-17-6-5-12(18-15)14-16-7-8-20-14/h3-9H,1-2H3,(H,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.82E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin)				Bioorg Med Chem Lett 18: 6231-5 (2008) Article DOI: 10.1016/j.bmcl.2008.09.106 BindingDB Entry DOI: 10.7270/Q25Q4VZT
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50249258 (CHEMBL475570 | N-(2,5-dimethylphenyl)-4-(thiazol-2...) Show SMILES Cc1ccc(C)c(Nc2nccc(n2)-c2nccs2)c1 Show InChI InChI=1S/C15H14N4S/c1-10-3-4-11(2)13(9-10)19-15-17-6-5-12(18-15)14-16-7-8-20-14/h3-9H,1-2H3,(H,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2 (unknown origin)				Bioorg Med Chem Lett 18: 6231-5 (2008) Article DOI: 10.1016/j.bmcl.2008.09.106 BindingDB Entry DOI: 10.7270/Q25Q4VZT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50249258 (CHEMBL475570 | N-(2,5-dimethylphenyl)-4-(thiazol-2...) Show SMILES Cc1ccc(C)c(Nc2nccc(n2)-c2nccs2)c1 Show InChI InChI=1S/C15H14N4S/c1-10-3-4-11(2)13(9-10)19-15-17-6-5-12(18-15)14-16-7-8-20-14/h3-9H,1-2H3,(H,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant Syk (unknown origin)				Bioorg Med Chem Lett 19: 1944-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.049 BindingDB Entry DOI: 10.7270/Q2WM1D98
					More data for this Ligand-Target Pair