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BDBM50249356 CHEMBL453217::N-(3,5-dimethylphenyl)-4-(4-methylthiazol-2-yl)pyrimidin-2-amine

SMILES: Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1

InChI Key: InChIKey=IUVDZGOUQXJDQC-UHFFFAOYSA-N

Data: 4 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50249356   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249356
PNG
(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Show SMILES Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-12(3)9-21-15/h4-9H,1-3H3,(H,17,19,20)
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56n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50249356
PNG
(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Show SMILES Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-12(3)9-21-15/h4-9H,1-3H3,(H,17,19,20)
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100n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50249356
PNG
(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Show SMILES Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-12(3)9-21-15/h4-9H,1-3H3,(H,17,19,20)
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1.03E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50249356
PNG
(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Show SMILES Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-12(3)9-21-15/h4-9H,1-3H3,(H,17,19,20)
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2.03E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SRC (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249356
PNG
(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Show SMILES Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-12(3)9-21-15/h4-9H,1-3H3,(H,17,19,20)
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n/an/a 56n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Syk (unknown origin)


Bioorg Med Chem Lett 19: 1944-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.049
BindingDB Entry DOI: 10.7270/Q2WM1D98
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249356
PNG
(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Show SMILES Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-12(3)9-21-15/h4-9H,1-3H3,(H,17,19,20)
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n/an/a 1.55E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)-mediated FCepsilonRI signaling activity by mast cell degranulation assay


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair