BDBM50249420 4-(5-methyl-1H-pyrazol-3-ylamino)-2-(2-oxo-2-phenylethyl)phthalazin-1(2H)-one::CHEMBL474651

SMILES: Cc1cc(Nc2nn(CC(=O)c3ccccc3)c(=O)c3ccccc23)[nH]n1

InChI Key: InChIKey=ZYWAUCIAPLYMIZ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50249420   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM50249420 (4-(5-methyl-1H-pyrazol-3-ylamino)-2-(2-oxo-2-pheny...) Show SMILES Cc1cc(Nc2nn(CC(=O)c3ccccc3)c(=O)c3ccccc23)[nH]n1 Show InChI InChI=1S/C20H17N5O2/c1-13-11-18(23-22-13)21-19-15-9-5-6-10-16(15)20(27)25(24-19)12-17(26)14-7-3-2-4-8-14/h2-11H,12H2,1H3,(H2,21,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Evotec (UK) Ltd. Curated by ChEMBL					Assay Description Inhibition of Aurora B by ELISA				J Med Chem 54: 312-9 (2011) Article DOI: 10.1021/jm101346r BindingDB Entry DOI: 10.7270/Q29P32MB
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50249420 (4-(5-methyl-1H-pyrazol-3-ylamino)-2-(2-oxo-2-pheny...) Show SMILES Cc1cc(Nc2nn(CC(=O)c3ccccc3)c(=O)c3ccccc23)[nH]n1 Show InChI InChI=1S/C20H17N5O2/c1-13-11-18(23-22-13)21-19-15-9-5-6-10-16(15)20(27)25(24-19)12-17(26)14-7-3-2-4-8-14/h2-11H,12H2,1H3,(H2,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Evotec (UK) Ltd. Curated by ChEMBL					Assay Description Inhibition of Aurora A by ELISA				J Med Chem 54: 312-9 (2011) Article DOI: 10.1021/jm101346r BindingDB Entry DOI: 10.7270/Q29P32MB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50249420 (4-(5-methyl-1H-pyrazol-3-ylamino)-2-(2-oxo-2-pheny...) Show SMILES Cc1cc(Nc2nn(CC(=O)c3ccccc3)c(=O)c3ccccc23)[nH]n1 Show InChI InChI=1S/C20H17N5O2/c1-13-11-18(23-22-13)21-19-15-9-5-6-10-16(15)20(27)25(24-19)12-17(26)14-7-3-2-4-8-14/h2-11H,12H2,1H3,(H2,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant Syk (unknown origin)				Bioorg Med Chem Lett 19: 1944-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.049 BindingDB Entry DOI: 10.7270/Q2WM1D98
					More data for this Ligand-Target Pair