BDBM50249658 3-acetyl-2-(3,5-bis(trifluoromethyl)phenylamino)-5,8-difluoroquinolin-4(1H)-one::CHEMBL491898

SMILES: CC(=O)c1c(Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)nc2c(F)ccc(F)c2c1O

InChI Key: InChIKey=VMYZPXZWGRNDJA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50249658   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calpain1 (Homo sapiens (Human))	BDBM50249658 (3-acetyl-2-(3,5-bis(trifluoromethyl)phenylamino)-5...) Show SMILES CC(=O)c1c(Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)nc2c(F)ccc(F)c2c1O Show InChI InChI=1S/C19H10F8N2O2/c1-7(30)13-16(31)14-11(20)2-3-12(21)15(14)29-17(13)28-10-5-8(18(22,23)24)4-9(6-10)19(25,26)27/h2-6H,1H3,(H2,28,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ewha Womans University Curated by ChEMBL					Assay Description Inhibition of human erythrocytes mu-calpain after 30 mins by fluorometric assay using pep1 as substrate				J Med Chem 52: 3093-7 (2009) Article DOI: 10.1021/jm8014734 BindingDB Entry DOI: 10.7270/Q2KK9CQ4
					More data for this Ligand-Target Pair