BDBM50249660 3-acetyl-8-chloro-2-(4-chloro-2-fluorophenylamino)-5-methylquinolin-4(1H)-one::CHEMBL491899

SMILES: CC(=O)c1c(O)c2c(C)ccc(Cl)c2nc1Nc1ccc(Cl)cc1F

InChI Key: InChIKey=ZOKOBEQQPDPBLR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50249660   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calpain1 (Homo sapiens (Human))	BDBM50249660 (3-acetyl-8-chloro-2-(4-chloro-2-fluorophenylamino)...) Show SMILES CC(=O)c1c(O)c2c(C)ccc(Cl)c2nc1Nc1ccc(Cl)cc1F Show InChI InChI=1S/C18H13Cl2FN2O2/c1-8-3-5-11(20)16-14(8)17(25)15(9(2)24)18(23-16)22-13-6-4-10(19)7-12(13)21/h3-7H,1-2H3,(H2,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ewha Womans University Curated by ChEMBL					Assay Description Inhibition of human erythrocytes mu-calpain after 30 mins by fluorometric assay using pep1 as substrate				J Med Chem 52: 3093-7 (2009) Article DOI: 10.1021/jm8014734 BindingDB Entry DOI: 10.7270/Q2KK9CQ4
					More data for this Ligand-Target Pair