BDBM50250930 CHEMBL4076473

SMILES: NC(=O)c1cn(nc1Nc1cc(F)c2nccc(Cl)c2c1)[C@H]1COCC[C@@H]1C#N

InChI Key: InChIKey=OVQWUMARSKIQAB-HWPZZCPQSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50250930   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50250930 (CHEMBL4076473) Show SMILES NC(=O)c1cn(nc1Nc1cc(F)c2nccc(Cl)c2c1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H16ClFN6O2/c20-14-1-3-24-17-12(14)5-11(6-15(17)21)25-19-13(18(23)28)8-27(26-19)16-9-29-4-2-10(16)7-22/h1,3,5-6,8,10,16H,2,4,9H2,(H2,23,28)(H,25,26)/t10-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co., Inc. Curated by ChEMBL					Assay Description Inhibition of GST-tagged recombinant human JAK3 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat...				J Med Chem 60: 9676-9690 (2017) Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50250930 (CHEMBL4076473) Show SMILES NC(=O)c1cn(nc1Nc1cc(F)c2nccc(Cl)c2c1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H16ClFN6O2/c20-14-1-3-24-17-12(14)5-11(6-15(17)21)25-19-13(18(23)28)8-27(26-19)16-9-29-4-2-10(16)7-22/h1,3,5-6,8,10,16H,2,4,9H2,(H2,23,28)(H,25,26)/t10-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co., Inc. Curated by ChEMBL					Assay Description Inhibition of GST-tagged recombinant human JAK1 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat...				J Med Chem 60: 9676-9690 (2017) Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50250930 (CHEMBL4076473) Show SMILES NC(=O)c1cn(nc1Nc1cc(F)c2nccc(Cl)c2c1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H16ClFN6O2/c20-14-1-3-24-17-12(14)5-11(6-15(17)21)25-19-13(18(23)28)8-27(26-19)16-9-29-4-2-10(16)7-22/h1,3,5-6,8,10,16H,2,4,9H2,(H2,23,28)(H,25,26)/t10-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co., Inc. Curated by ChEMBL					Assay Description Inhibition of JAK1 in IL6-stimulated human ME180 cells expressing stably integrated beta-lactamase reporter gene under control of sis-inducible eleme...				J Med Chem 60: 9676-9690 (2017) Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50250930 (CHEMBL4076473) Show SMILES NC(=O)c1cn(nc1Nc1cc(F)c2nccc(Cl)c2c1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H16ClFN6O2/c20-14-1-3-24-17-12(14)5-11(6-15(17)21)25-19-13(18(23)28)8-27(26-19)16-9-29-4-2-10(16)7-22/h1,3,5-6,8,10,16H,2,4,9H2,(H2,23,28)(H,25,26)/t10-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	608	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co., Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 in EPO-stimulated human TF1 cells expressing stably integrated beta-lactamase reporter gene under control of STAT5 response elemen...				J Med Chem 60: 9676-9690 (2017) Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50250930 (CHEMBL4076473) Show SMILES NC(=O)c1cn(nc1Nc1cc(F)c2nccc(Cl)c2c1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H16ClFN6O2/c20-14-1-3-24-17-12(14)5-11(6-15(17)21)25-19-13(18(23)28)8-27(26-19)16-9-29-4-2-10(16)7-22/h1,3,5-6,8,10,16H,2,4,9H2,(H2,23,28)(H,25,26)/t10-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co., Inc. Curated by ChEMBL					Assay Description Inhibition of GST-tagged recombinant human JAK2 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat...				J Med Chem 60: 9676-9690 (2017) Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50250930 (CHEMBL4076473) Show SMILES NC(=O)c1cn(nc1Nc1cc(F)c2nccc(Cl)c2c1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H16ClFN6O2/c20-14-1-3-24-17-12(14)5-11(6-15(17)21)25-19-13(18(23)28)8-27(26-19)16-9-29-4-2-10(16)7-22/h1,3,5-6,8,10,16H,2,4,9H2,(H2,23,28)(H,25,26)/t10-,16+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co., Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged recombinant human TYK2 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 ...				J Med Chem 60: 9676-9690 (2017) Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD
					More data for this Ligand-Target Pair