Found 7 hits for monomerid = 50250933 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50250933
(CHEMBL4077886)Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C1CC1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H21N5O2/c20-9-14-7-8-26-11-17(14)24-10-16(18(21)25)19(23-24)22-15-5-3-13(4-6-15)12-1-2-12/h3-6,10,12,14,17H,1-2,7-8,11H2,(H2,21,25)(H,22,23)/t14-,17+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc.
Curated by ChEMBL
| Assay Description Inhibition of N-terminal GST-tagged recombinant human TYK2 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 ... |
J Med Chem 60: 9676-9690 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50250933
(CHEMBL4077886)Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C1CC1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H21N5O2/c20-9-14-7-8-26-11-17(14)24-10-16(18(21)25)19(23-24)22-15-5-3-13(4-6-15)12-1-2-12/h3-6,10,12,14,17H,1-2,7-8,11H2,(H2,21,25)(H,22,23)/t14-,17+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc.
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged recombinant human JAK1 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat... |
J Med Chem 60: 9676-9690 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50250933
(CHEMBL4077886)Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C1CC1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H21N5O2/c20-9-14-7-8-26-11-17(14)24-10-16(18(21)25)19(23-24)22-15-5-3-13(4-6-15)12-1-2-12/h3-6,10,12,14,17H,1-2,7-8,11H2,(H2,21,25)(H,22,23)/t14-,17+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in EPO-stimulated human TF1 cells expressing stably integrated beta-lactamase reporter gene under control of STAT5 response elemen... |
J Med Chem 60: 9676-9690 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50250933
(CHEMBL4077886)Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C1CC1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H21N5O2/c20-9-14-7-8-26-11-17(14)24-10-16(18(21)25)19(23-24)22-15-5-3-13(4-6-15)12-1-2-12/h3-6,10,12,14,17H,1-2,7-8,11H2,(H2,21,25)(H,22,23)/t14-,17+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in EPO-stimulated human TF1 cells expressing stably integrated beta-lactamase reporter gene under control of STAT5 response elemen... |
J Med Chem 60: 9676-9690 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50250933
(CHEMBL4077886)Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C1CC1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H21N5O2/c20-9-14-7-8-26-11-17(14)24-10-16(18(21)25)19(23-24)22-15-5-3-13(4-6-15)12-1-2-12/h3-6,10,12,14,17H,1-2,7-8,11H2,(H2,21,25)(H,22,23)/t14-,17+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc.
Curated by ChEMBL
| Assay Description Displacement of [35S]-MK499 from human ERG expressed in HEK293 cell membranes |
J Med Chem 60: 9676-9690 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50250933
(CHEMBL4077886)Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C1CC1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H21N5O2/c20-9-14-7-8-26-11-17(14)24-10-16(18(21)25)19(23-24)22-15-5-3-13(4-6-15)12-1-2-12/h3-6,10,12,14,17H,1-2,7-8,11H2,(H2,21,25)(H,22,23)/t14-,17+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK1 in IL6-stimulated human ME180 cells expressing stably integrated beta-lactamase reporter gene under control of sis-inducible eleme... |
J Med Chem 60: 9676-9690 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50250933
(CHEMBL4077886)Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C1CC1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H21N5O2/c20-9-14-7-8-26-11-17(14)24-10-16(18(21)25)19(23-24)22-15-5-3-13(4-6-15)12-1-2-12/h3-6,10,12,14,17H,1-2,7-8,11H2,(H2,21,25)(H,22,23)/t14-,17+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc.
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged recombinant human JAK3 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrat... |
J Med Chem 60: 9676-9690 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01135 BindingDB Entry DOI: 10.7270/Q20867RD |
More data for this Ligand-Target Pair | |