BDBM50251127 Bis(2-((2-(7-chloro-6-oxo-6H-dibenzo[cd,g]indazol-2-yl)-ethyl)-methyl-amino)-ethyl) adipate dihydrochloride::CHEMBL453166
SMILES: CN(CCOC(=O)CCCCC(=O)OCCN(C)CCn1nc2-c3cccc(Cl)c3C(=O)c3cccc1c23)CCn1nc2-c3cccc(Cl)c3C(=O)c3cccc1c23
InChI Key: InChIKey=URTDSECLQCJXGV-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM50251127 (Bis(2-((2-(7-chloro-6-oxo-6H-dibenzo[cd,g]indazol-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manitoba Curated by ChEMBL | Assay Description Inhibition of human topoisomerase 2alpha decantation activity | Bioorg Med Chem 16: 3959-68 (2008) Article DOI: 10.1016/j.bmc.2008.01.033 BindingDB Entry DOI: 10.7270/Q2T72H7K | |||||||||||
More data for this Ligand-Target Pair |