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SMILES: Cc1cc(Nc2nc(nc3ccc(Cl)cc23)C(=O)NC2CNC2)n[nH]1

InChI Key: InChIKey=NEGLMAZWTJTKJA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50251176   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase PAK 4


(Homo sapiens (Human))		BDBM50251176
PNG
(CHEMBL4087672)
Show SMILES Cc1cc(Nc2nc(nc3ccc(Cl)cc23)C(=O)NC2CNC2)n[nH]1
Show InChI InChI=1S/C16H16ClN7O/c1-8-4-13(24-23-8)21-14-11-5-9(17)2-3-12(11)20-15(22-14)16(25)19-10-6-18-7-10/h2-5,10,18H,6-7H2,1H3,(H,19,25)(H2,20,21,22,23,24)
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Similars
Article
PubMed
 782n/an/an/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human PAK4 kinase domain using coumarin and fluorescein-labeled ser/thr20 peptide as substrate preincubated for 15 mins followed by ATP...

J Med Chem 61: 265-285 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01342
BindingDB Entry DOI: 10.7270/Q2BK1FSN
More data for this
Ligand-Target Pair