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SMILES: CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)Nc1cc(OC)ccc1-c1ccccc1

InChI Key: InChIKey=NNLBMSQVKKQKCE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50251784   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
C5a anaphylatoxin chemotactic receptor 1


(Homo sapiens (Human))		BDBM50251784
PNG
(CHEMBL479539 | [2-(2,6-Diethyl-phenyl)-4-methoxy-5...)
Show SMILES CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)Nc1cc(OC)ccc1-c1ccccc1
Show InChI InChI=1S/C33H36N2O2/c1-5-22-14-10-15-23(6-2)32(22)30-21-31(37-4)33-27(16-11-17-28(33)35-30)34-29-20-25(36-3)18-19-26(29)24-12-8-7-9-13-24/h7-10,12-15,18-21,27,34H,5-6,11,16-17H2,1-4H3
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Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant C5a receptor in U937 cells assessed as inhibition of C5a-induced calcium mobilization by FLIPR assay

Bioorg Med Chem Lett 18: 3852-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.059
BindingDB Entry DOI: 10.7270/Q2765F4X
More data for this
Ligand-Target Pair