BDBM50251846 2-(2-(2,6-diethylphenyl)-4-methoxy-5,6,7,8-tetrahydroquinolin-5-ylamino)benzonitrile::CHEMBL519456
SMILES: CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)Nc1ccccc1C#N
InChI Key: InChIKey=FFSLJNPGKCOLQL-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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C5a anaphylatoxin chemotactic receptor (C5aR) (Homo sapiens (Human)) | BDBM50251846 (2-(2-(2,6-diethylphenyl)-4-methoxy-5,6,7,8-tetrahy...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human recombinant C5a receptor in U937 cells assessed as inhibition of C5a-induced calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 18: 3852-5 (2008) Article DOI: 10.1016/j.bmcl.2008.06.059 BindingDB Entry DOI: 10.7270/Q2765F4X | |||||||||||
More data for this Ligand-Target Pair |