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BDBM50251911 CHEMBL452471::{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imidazol-5-yl]-pyridin-2-yl}-thiophen-2-ylmethylamine

SMILES: CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(NCc2cccs2)c1

InChI Key: InChIKey=JLPTWLXBWHFIGE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50251911   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50251911
PNG
(CHEMBL452471 | {4-[4-(4-Fluoro-phenyl)-2-methylsul...)
Show SMILES CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(NCc2cccs2)c1
Show InChI InChI=1S/C20H17FN4S2/c1-26-20-24-18(13-4-6-15(21)7-5-13)19(25-20)14-8-9-22-17(11-14)23-12-16-3-2-10-27-16/h2-11H,12H2,1H3,(H,22,23)(H,24,25)
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 46n/an/an/an/an/an/a



Eberhard-Karls-University Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38alpha


J Med Chem 51: 4122-49 (2008)


Article DOI: 10.1021/jm701529q
BindingDB Entry DOI: 10.7270/Q2W37X67
More data for this
Ligand-Target Pair