BDBM50251924 CHEMBL481751::trans-{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imidazol-5-yl]-pyridin-2-yl}-(4-methylcyclohexyl)-amine

SMILES: CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(N[C@H]2CC[C@H](C)CC2)c1

InChI Key: InChIKey=DDHYZAOORBKEHA-PPUGGXLSSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50251924   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50251924 (CHEMBL481751 | trans-{4-[4-(4-Fluoro-phenyl)-2-met...) Show SMILES CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(N[C@H]2CC[C@H](C)CC2)c1 |r,wU:20.21,wD:23.25,(2.16,-47.39,;1.39,-46.06,;-.15,-46.05,;-1.06,-47.29,;-2.52,-46.82,;-2.51,-45.27,;-1.05,-44.8,;-3.84,-44.5,;-3.83,-42.96,;-5.16,-42.18,;-6.5,-42.94,;-7.83,-42.16,;-6.5,-44.49,;-5.17,-45.26,;-3.85,-47.58,;-5.18,-46.81,;-6.52,-47.58,;-6.52,-49.12,;-5.17,-49.89,;-5.17,-51.43,;-3.83,-52.19,;-2.49,-51.42,;-1.16,-52.19,;-1.16,-53.73,;.18,-54.5,;-2.48,-54.5,;-3.81,-53.73,;-3.85,-49.11,)| Show InChI InChI=1S/C22H25FN4S/c1-14-3-9-18(10-4-14)25-19-13-16(11-12-24-19)21-20(26-22(27-21)28-2)15-5-7-17(23)8-6-15/h5-8,11-14,18H,3-4,9-10H2,1-2H3,(H,24,25)(H,26,27)/t14-,18-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University Tuebingen Curated by ChEMBL					Assay Description Inhibition of p38alpha				J Med Chem 51: 4122-49 (2008) Article DOI: 10.1021/jm701529q BindingDB Entry DOI: 10.7270/Q2W37X67
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