BDBM50253474 5-(5-(Cyclopropylethynyl)thiophen-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide::CHEMBL493916

SMILES: Cc1c(nn(c1-c1ccc(s1)C#CC1CC1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1

InChI Key: InChIKey=PZSBYWQVUJSNFN-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50253474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50253474 (5-(5-(Cyclopropylethynyl)thiophen-2-yl)-1-(2,4-dic...) Show SMILES Cc1c(nn(c1-c1ccc(s1)C#CC1CC1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 Show InChI InChI=1S/C25H24Cl2N4OS/c1-16-23(25(32)29-30-13-3-2-4-14-30)28-31(21-11-8-18(26)15-20(21)27)24(16)22-12-10-19(33-22)9-7-17-5-6-17/h8,10-12,15,17H,2-6,13-14H2,1H3,(H,29,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	60.4	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells				J Med Chem 51: 5397-412 (2008) Article DOI: 10.1021/jm800066v BindingDB Entry DOI: 10.7270/Q24M94BM
					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50253474 (5-(5-(Cyclopropylethynyl)thiophen-2-yl)-1-(2,4-dic...) Show SMILES Cc1c(nn(c1-c1ccc(s1)C#CC1CC1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 Show InChI InChI=1S/C25H24Cl2N4OS/c1-16-23(25(32)29-30-13-3-2-4-14-30)28-31(21-11-8-18(26)15-20(21)27)24(16)22-12-10-19(33-22)9-7-17-5-6-17/h8,10-12,15,17H,2-6,13-14H2,1H3,(H,29,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	72.9	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Antagonist activity at human CB1 receptor expressed in HEK293 cells assessed as inhibition of Eu-GTP binding				J Med Chem 51: 5397-412 (2008) Article DOI: 10.1021/jm800066v BindingDB Entry DOI: 10.7270/Q24M94BM
					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50253474 (5-(5-(Cyclopropylethynyl)thiophen-2-yl)-1-(2,4-dic...) Show SMILES Cc1c(nn(c1-c1ccc(s1)C#CC1CC1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 Show InChI InChI=1S/C25H24Cl2N4OS/c1-16-23(25(32)29-30-13-3-2-4-14-30)28-31(21-11-8-18(26)15-20(21)27)24(16)22-12-10-19(33-22)9-7-17-5-6-17/h8,10-12,15,17H,2-6,13-14H2,1H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Displacement of [3H]CP55940 from human CB2 receptor expressed in HEK293 cells				J Med Chem 51: 5397-412 (2008) Article DOI: 10.1021/jm800066v BindingDB Entry DOI: 10.7270/Q24M94BM
					More data for this Ligand-Target Pair