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BDBM50254190 CHEMBL4062656

SMILES: COc1cc2CN(Cc2cc1OC)C(=O)Nc1ccc(cc1)C(=O)NCCC(C)C

InChI Key: InChIKey=GWWNERDQHKQIBF-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50254190   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50254190
PNG
(CHEMBL4062656)
Show SMILES COc1cc2CN(Cc2cc1OC)C(=O)Nc1ccc(cc1)C(=O)NCCC(C)C
Show InChI InChI=1S/C23H29N3O4/c1-15(2)9-10-24-22(27)16-5-7-19(8-6-16)25-23(28)26-13-17-11-20(29-3)21(30-4)12-18(17)14-26/h5-8,11-12,15H,9-10,13-14H2,1-4H3,(H,24,27)(H,25,28)
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Similars
Article
PubMed
>9.00E+3n/an/an/an/an/an/an/an/a



AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States. Electronic address: mike.curtin@abbvie.com.

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-...

Bioorg Med Chem Lett 27: 3317-3325 (2017)


Article DOI: 10.1016/j.bmcl.2017.06.018
BindingDB Entry DOI: 10.7270/Q2D22123
More data for this
Ligand-Target Pair