Found 3 hits for monomerid = 50255179 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50255179
(CHEMBL519939 | N-(4-(5-fluoro-6-methylpyridin-2-yl...)Show SMILES CC(=O)Nc1nc(c([nH]1)-c1ccc2nccnc2c1)-c1ccc(F)c(C)n1 Show InChI InChI=1S/C19H15FN6O/c1-10-13(20)4-6-15(23-10)18-17(25-19(26-18)24-11(2)27)12-3-5-14-16(9-12)22-8-7-21-14/h3-9H,1-2H3,(H2,24,25,26,27) | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 7.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbot Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to human TGFBR1 |
Bioorg Med Chem Lett 19: 912-6 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.119 BindingDB Entry DOI: 10.7270/Q2FX799C |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50255179
(CHEMBL519939 | N-(4-(5-fluoro-6-methylpyridin-2-yl...)Show SMILES CC(=O)Nc1nc(c([nH]1)-c1ccc2nccnc2c1)-c1ccc(F)c(C)n1 Show InChI InChI=1S/C19H15FN6O/c1-10-13(20)4-6-15(23-10)18-17(25-19(26-18)24-11(2)27)12-3-5-14-16(9-12)22-8-7-21-14/h3-9H,1-2H3,(H2,24,25,26,27) | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 1.48E+4 | n/a | n/a | n/a | n/a |
Abbot Laboratories
Curated by ChEMBL
| Assay Description Inhibition of p38alpha (unknown origin) |
Bioorg Med Chem Lett 19: 912-6 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.119 BindingDB Entry DOI: 10.7270/Q2FX799C |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50255179
(CHEMBL519939 | N-(4-(5-fluoro-6-methylpyridin-2-yl...)Show SMILES CC(=O)Nc1nc(c([nH]1)-c1ccc2nccnc2c1)-c1ccc(F)c(C)n1 Show InChI InChI=1S/C19H15FN6O/c1-10-13(20)4-6-15(23-10)18-17(25-19(26-18)24-11(2)27)12-3-5-14-16(9-12)22-8-7-21-14/h3-9H,1-2H3,(H2,24,25,26,27) | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
Abbot Laboratories
Curated by ChEMBL
| Assay Description Inhibition of TGFBR1 (unknown origin) transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assay |
Bioorg Med Chem Lett 19: 912-6 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.119 BindingDB Entry DOI: 10.7270/Q2FX799C |
More data for this Ligand-Target Pair | 3D Structure (crystal) |