BDBM50255228 CHEMBL517068::N-(5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(5-fluoro-6-methylpyridin-2-yl)-1H-imidazol-2-yl)acetamide

SMILES: CC(=O)Nc1nc(c([nH]1)-c1ccc2ncnn2c1)-c1ccc(F)c(C)n1

InChI Key: InChIKey=CLWJRULKTFGNLL-UHFFFAOYSA-N

Data: 1 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50255228   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50255228 (CHEMBL517068 | N-(5-([1,2,4]triazolo[1,5-a]pyridin...) Show SMILES CC(=O)Nc1nc(c([nH]1)-c1ccc2ncnn2c1)-c1ccc(F)c(C)n1 Show InChI InChI=1S/C17H14FN7O/c1-9-12(18)4-5-13(21-9)16-15(23-17(24-16)22-10(2)26)11-3-6-14-19-8-20-25(14)7-11/h3-8H,1-2H3,(H2,22,23,24,26)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.07	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbot Laboratories Curated by ChEMBL					Assay Description Binding affinity to human TGFBR1				Bioorg Med Chem Lett 19: 912-6 (2009) Article DOI: 10.1016/j.bmcl.2008.11.119 BindingDB Entry DOI: 10.7270/Q2FX799C
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50255228 (CHEMBL517068 | N-(5-([1,2,4]triazolo[1,5-a]pyridin...) Show SMILES CC(=O)Nc1nc(c([nH]1)-c1ccc2ncnn2c1)-c1ccc(F)c(C)n1 Show InChI InChI=1S/C17H14FN7O/c1-9-12(18)4-5-13(21-9)16-15(23-17(24-16)22-10(2)26)11-3-6-14-19-8-20-25(14)7-11/h3-8H,1-2H3,(H2,22,23,24,26)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.81E+4	n/a	n/a	n/a	n/a
Abbot Laboratories Curated by ChEMBL					Assay Description Inhibition of p38alpha (unknown origin)				Bioorg Med Chem Lett 19: 912-6 (2009) Article DOI: 10.1016/j.bmcl.2008.11.119 BindingDB Entry DOI: 10.7270/Q2FX799C
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50255228 (CHEMBL517068 | N-(5-([1,2,4]triazolo[1,5-a]pyridin...) Show SMILES CC(=O)Nc1nc(c([nH]1)-c1ccc2ncnn2c1)-c1ccc(F)c(C)n1 Show InChI InChI=1S/C17H14FN7O/c1-9-12(18)4-5-13(21-9)16-15(23-17(24-16)22-10(2)26)11-3-6-14-19-8-20-25(14)7-11/h3-8H,1-2H3,(H2,22,23,24,26)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	111	n/a	n/a	n/a	n/a
Abbot Laboratories Curated by ChEMBL					Assay Description Inhibition of TGFBR1 (unknown origin) transfected in human HepG2 cells after 24 hrs by plasminogen activator inhibitor-luciferase reporter gene assay				Bioorg Med Chem Lett 19: 912-6 (2009) Article DOI: 10.1016/j.bmcl.2008.11.119 BindingDB Entry DOI: 10.7270/Q2FX799C
					More data for this Ligand-Target Pair