BDBM50255793 1-[3-(4-Methyl-piperazine-1-carbonyl)-phenyl]-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one::CHEMBL520924

SMILES: CN1CCN(CC1)C(=O)c1cccc(c1)-c1nc2cccc3C(=O)NCCn1c23

InChI Key: InChIKey=OYQFNAXNQDFONR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50255793   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50255793 (1-[3-(4-Methyl-piperazine-1-carbonyl)-phenyl]-8,9-...) Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1nc2cccc3C(=O)NCCn1c23 Show InChI InChI=1S/C22H23N5O2/c1-25-10-12-26(13-11-25)22(29)16-5-2-4-15(14-16)20-24-18-7-3-6-17-19(18)27(20)9-8-23-21(17)28/h2-7,14H,8-13H2,1H3,(H,23,28)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	161	n/a	n/a	n/a	n/a	n/a	n/a
Huazhong University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of human recombinant PARP1				J Med Chem 52: 718-25 (2009) Article DOI: 10.1021/jm800902t BindingDB Entry DOI: 10.7270/Q2C53KPW
					More data for this Ligand-Target Pair