BDBM50255926 CHEMBL4063067

SMILES: CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC)c1Cl

InChI Key: InChIKey=AFGNZVNCHBBTQP-DEOSSOPVSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50255926   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50255926 (CHEMBL4063067) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC)c1Cl |r| Show InChI InChI=1S/C32H39ClN8O3/c1-5-28(42)39-12-11-24(20-39)41-30-22(19-40(32(41)43)26-7-6-8-27(44-4)29(26)33)18-34-31(36-30)35-23-9-10-25(21(2)17-23)38-15-13-37(3)14-16-38/h6-10,17-18,24H,5,11-16,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50255926 (CHEMBL4063067) Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC)c1Cl |r| Show InChI InChI=1S/C32H39ClN8O3/c1-5-28(42)39-12-11-24(20-39)41-30-22(19-40(32(41)43)26-7-6-8-27(44-4)29(26)33)18-34-31(36-30)35-23-9-10-25(21(2)17-23)38-15-13-37(3)14-16-38/h6-10,17-18,24H,5,11-16,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	413	n/a	n/a	n/a	n/a	n/a	n/a
State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China. Curated by ChEMBL					Assay Description Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...				J Med Chem 61: 2353-2371 (2018) Article DOI: 10.1021/acs.jmedchem.7b01612 BindingDB Entry DOI: 10.7270/Q2NC63NB
					More data for this Ligand-Target Pair