BDBM50256229 CHEMBL4063752

SMILES: C[C@H]1CN(CCN1c1ncc(cn1)C(F)(F)F)C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1

InChI Key: InChIKey=WKCWHWQATMIGEI-ZDUSSCGKSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50256229   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human))	BDBM50256229 (CHEMBL4063752) Show SMILES C[C@H]1CN(CCN1c1ncc(cn1)C(F)(F)F)C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1 |r| Show InChI InChI=1S/C24H23F3N8OS2/c1-13-11-34(6-7-35(13)22-29-9-17(10-30-22)24(25,26)27)21(36)16-4-5-19(28-8-16)33-23-32-18(12-37-23)20-14(2)31-15(3)38-20/h4-5,8-10,12-13H,6-7,11H2,1-3H3,(H,28,32,33)/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi& Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...				Bioorg Med Chem 25: 2177-2190 (2017) Article DOI: 10.1016/j.bmc.2017.02.047 BindingDB Entry DOI: 10.7270/Q2N58PT9
					More data for this Ligand-Target Pair
Vanilloid receptor (Rattus norvegicus)	BDBM50256229 (CHEMBL4063752) Show SMILES C[C@H]1CN(CCN1c1ncc(cn1)C(F)(F)F)C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1 |r| Show InChI InChI=1S/C24H23F3N8OS2/c1-13-11-34(6-7-35(13)22-29-9-17(10-30-22)24(25,26)27)21(36)16-4-5-19(28-8-16)33-23-32-18(12-37-23)20-14(2)31-15(3)38-20/h4-5,8-10,12-13H,6-7,11H2,1-3H3,(H,28,32,33)/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi& Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...				Bioorg Med Chem 25: 2177-2190 (2017) Article DOI: 10.1016/j.bmc.2017.02.047 BindingDB Entry DOI: 10.7270/Q2N58PT9
					More data for this Ligand-Target Pair