BindingDB PrimarySearch

BDBM50257294 7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one::CHEMBL492717

SMILES: Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccccc1

InChI Key: InChIKey=AMBSKUOANQGADA-UHFFFAOYSA-N

Data: 3 KI 2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50257294
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human))	BDBM50257294 (7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Modena and R.E. Curated by ChEMBL					Assay Description Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by mixed type inhibition assay				Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F
University of Modena and R.E. Curated by ChEMBL					More data for this Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human))	BDBM50257294 (7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Modena and R.E. Curated by ChEMBL					Assay Description Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by mixed type inhibition assay				Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F
University of Modena and R.E. Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50257294 (7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.91E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Modena and R.E. Curated by ChEMBL					Assay Description Inhibition of human cloned PTP1B expressed in Escherichia coli TB1 by mixed type inhibition assay				Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F
University of Modena and R.E. Curated by ChEMBL					More data for this Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human))	BDBM50257294 (7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Modena and R.E. Curated by ChEMBL					Assay Description Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1				Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F
University of Modena and R.E. Curated by ChEMBL					More data for this Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human))	BDBM50257294 (7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Modena and R.E. Curated by ChEMBL					Assay Description Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1				Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F
University of Modena and R.E. Curated by ChEMBL					More data for this Ligand-Target Pair