BDBM50257612 CHEMBL493950::N-benzyl-N-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7-sulfonamide
SMILES: CN(Cc1ccccc1)S(=O)(=O)c1ccc2CCNCCc2c1
InChI Key: InChIKey=JHQGAWPRLWOPNO-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50257612 (CHEMBL493950 | N-benzyl-N-methyl-2,3,4,5-tetrahydr...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay | Bioorg Med Chem Lett 19: 1871-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.071 BindingDB Entry DOI: 10.7270/Q2GB23XH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50257612 (CHEMBL493950 | N-benzyl-N-methyl-2,3,4,5-tetrahydr...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >9.94E+3 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Agonist activity at human recombinant 5HT2B receptor by cell-based system | Bioorg Med Chem Lett 19: 1871-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.071 BindingDB Entry DOI: 10.7270/Q2GB23XH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50257612 (CHEMBL493950 | N-benzyl-N-methyl-2,3,4,5-tetrahydr...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 94 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 19: 1871-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.071 BindingDB Entry DOI: 10.7270/Q2GB23XH | |||||||||||
More data for this Ligand-Target Pair |