BDBM50257618 (S)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine::CHEMBL492557
SMILES: Clc1ccccc1O[C@H]1CCN(C1)S(=O)(=O)c1ccc2CCNCCc2c1
InChI Key: InChIKey=ZKXGFMNPUCAFKG-KRWDZBQOSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50257618 ((S)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Binding affinity to human ERG | Bioorg Med Chem Lett 19: 1871-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.071 BindingDB Entry DOI: 10.7270/Q2GB23XH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50257618 ((S)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >9.94E+3 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Agonist activity at human recombinant 5HT2B receptor by cell-based system | Bioorg Med Chem Lett 19: 1871-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.071 BindingDB Entry DOI: 10.7270/Q2GB23XH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50257618 ((S)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay | Bioorg Med Chem Lett 19: 1871-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.071 BindingDB Entry DOI: 10.7270/Q2GB23XH | |||||||||||
More data for this Ligand-Target Pair |