BDBM50258330 2-(4-Fluorophenyl)-5-(6-methylpyridin-2-ylethynyl)benzonitrile::CHEMBL493774

SMILES: Fc1ccc(cc1)-c1ccc(cc1C#N)C#Cc1ccccn1

InChI Key: InChIKey=YBKQCXGQEJFHSX-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50258330   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50258330 (2-(4-Fluorophenyl)-5-(6-methylpyridin-2-ylethynyl)...) Show SMILES Fc1ccc(cc1)-c1ccc(cc1C#N)C#Cc1ccccn1 Show InChI InChI=1S/C20H11FN2/c21-18-8-6-16(7-9-18)20-11-5-15(13-17(20)14-22)4-10-19-3-1-2-12-23-19/h1-3,5-9,11-13H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from rat brain recombinant mGluR5 expressed in HEK293T cells by scintillation counting				J Med Chem 52: 3563-75 (2009) Article DOI: 10.1021/jm900172f BindingDB Entry DOI: 10.7270/Q2K937FV
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50258330 (2-(4-Fluorophenyl)-5-(6-methylpyridin-2-ylethynyl)...) Show SMILES Fc1ccc(cc1)-c1ccc(cc1C#N)C#Cc1ccccn1 Show InChI InChI=1S/C20H11FN2/c21-18-8-6-16(7-9-18)20-11-5-15(13-17(20)14-22)4-10-19-3-1-2-12-23-19/h1-3,5-9,11-13H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...				J Med Chem 52: 3563-75 (2009) Article DOI: 10.1021/jm900172f BindingDB Entry DOI: 10.7270/Q2K937FV
					More data for this Ligand-Target Pair