BDBM50258389 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(3-(piperazin-1-ylmethylamino)propoxy)phenyl)nicotinonitrile::CHEMBL493825
SMILES: CN1CCN(CCCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
InChI Key: InChIKey=REVNTLJVVFYWNE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50258389 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50258389
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(3-(piperazin...)Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C29H32N6O/c1-21-25-10-11-32-28(25)9-8-27(21)33-29-23(18-30)19-31-20-26(29)22-4-6-24(7-5-22)36-17-3-12-35-15-13-34(2)14-16-35/h4-11,19-20,32H,3,12-17H2,1-2H3,(H,31,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human PKCdelta by IMAP assay |
Bioorg Med Chem Lett 19: 3623-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.126 BindingDB Entry DOI: 10.7270/Q29W0FD4 |
More data for this Ligand-Target Pair | |
Protein kinase C theta type
(Homo sapiens (Human)) | BDBM50258389
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(3-(piperazin...)Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1 Show InChI InChI=1S/C29H32N6O/c1-21-25-10-11-32-28(25)9-8-27(21)33-29-23(18-30)19-31-20-26(29)22-4-6-24(7-5-22)36-17-3-12-35-15-13-34(2)14-16-35/h4-11,19-20,32H,3,12-17H2,1-2H3,(H,31,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human PKCtheta by IMAP assay |
Bioorg Med Chem Lett 19: 3623-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.126 BindingDB Entry DOI: 10.7270/Q29W0FD4 |
More data for this Ligand-Target Pair | |