BDBM50258426 CHEMBL521850::N-methyl-N-(1-methylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-amine

SMILES: CN(C1CCN(C)CC1)c1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2n1

InChI Key: InChIKey=FLOQWWLPIRCNAE-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50258426   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50258426 (CHEMBL521850 | N-methyl-N-(1-methylpiperidin-4-yl)...) Show SMILES CN(C1CCN(C)CC1)c1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2n1 Show InChI InChI=1S/C19H21F3N6/c1-26-10-8-15(9-11-26)27(2)17-7-6-16-23-24-18(28(16)25-17)13-4-3-5-14(12-13)19(20,21)22/h3-7,12,15H,8-11H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...				Bioorg Med Chem Lett 19: 3019-22 (2009) Article DOI: 10.1016/j.bmcl.2009.04.061 BindingDB Entry DOI: 10.7270/Q21J99PJ
					More data for this Ligand-Target Pair