BindingDB PrimarySearch

BDBM50258529 CHEMBL449158::bryostatin 1

SMILES: CCC\C=C\C=C\C(=O)O[C@H]1\C(C[C@H]2C[C@@H](OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C\C(C[C@@H](O4)\C=C\C(C)(C)[C@]1(O)O2)=C\C(=O)OC)O3)[C@@H](C)O)=C\C(=O)OC

InChI Key: InChIKey=MJQUEDHRCUIRLF-TVIXENOKSA-N

Data: 3 KI 5 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50258529
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein kinase C delta type (Homo sapiens (Human))	BDBM50258529 (CHEMBL449158 \| bryostatin 1) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	0.440	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Helsinki Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from human recombinant PKCdelta expressed in Sf9 cells by liquid scintillation counting				J Med Chem 52: 3969-81 (2009) Article DOI: 10.1021/jm900229p BindingDB Entry DOI: 10.7270/Q2ZK5GJ1
University of Helsinki Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50258529 (CHEMBL449158 \| bryostatin 1) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of [20-3H]phorbol 12,13-dibutyrate binding to human PKCalpha by scintillation counting based poly(ethylene) glycol precipitation assay				J Nat Prod 78: 896-900 (2015) Article DOI: 10.1021/acs.jnatprod.5b00094 BindingDB Entry DOI: 10.7270/Q2ZK5JD2
National Cancer Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, PKC; classical/novel (Homo sapiens (Human))	BDBM50258529 (CHEMBL449158 \| bryostatin 1) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Curated by ChEMBL					Assay Description Inhibition of [3H]PDBu binding to recombinant full length human PKCdelta expressed in baculovirus expression system incubated for 5 mins by scintilla...				J Nat Prod 79: 680-4 (2016) Article DOI: 10.1021/acs.jnatprod.5b01017
Stanford University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM50258529 (CHEMBL449158 \| bryostatin 1) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a
National Cancer Institute									ACS Chem Biol 8: 767-77 (2013) Article DOI: 10.1021/cb300671s BindingDB Entry DOI: 10.7270/Q20V8BF7
National Cancer Institute					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50258529 (CHEMBL449158 \| bryostatin 1) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a
National Cancer Institute									ACS Chem Biol 8: 767-77 (2013) Article DOI: 10.1021/cb300671s BindingDB Entry DOI: 10.7270/Q20V8BF7
National Cancer Institute					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50258529 (CHEMBL449158 \| bryostatin 1) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a
National Cancer Institute									ACS Chem Biol 8: 767-77 (2013) Article DOI: 10.1021/cb300671s BindingDB Entry DOI: 10.7270/Q20V8BF7
National Cancer Institute					More data for this Ligand-Target Pair
PKC alpha [mouse] (Mus musculus)	BDBM50258529 (CHEMBL449158 \| bryostatin 1) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a
National Cancer Institute									ACS Chem Biol 8: 767-77 (2013) Article DOI: 10.1021/cb300671s BindingDB Entry DOI: 10.7270/Q20V8BF7
National Cancer Institute					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50258529 (CHEMBL449158 \| bryostatin 1) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a
National Cancer Institute									ACS Chem Biol 8: 767-77 (2013) Article DOI: 10.1021/cb300671s BindingDB Entry DOI: 10.7270/Q20V8BF7
National Cancer Institute					More data for this Ligand-Target Pair