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BDBM50258812 CHEMBL468297::N-cyclopropyl-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-6-amine

SMILES: C1CC1Nc1ccc2nnc(-c3ccccc3)n2n1

InChI Key: InChIKey=RCJWOHKIDMXOTM-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50258812   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50258812
PNG
(CHEMBL468297 | N-cyclopropyl-3-phenyl-[1,2,4]triaz...)
Show SMILES C1CC1Nc1ccc2nnc(-c3ccccc3)n2n1
Show InChI InChI=1S/C14H13N5/c1-2-4-10(5-3-1)14-17-16-13-9-8-12(18-19(13)14)15-11-6-7-11/h1-5,8-9,11H,6-7H2,(H,15,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
1.80E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...


Bioorg Med Chem Lett 19: 3019-22 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.061
BindingDB Entry DOI: 10.7270/Q21J99PJ
More data for this
Ligand-Target Pair