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BDBM50258853 CHEMBL468940::N-cyclopropyl-3-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-amine

SMILES: FC(F)(F)c1cccc(c1)-c1nnc2ccc(NC3CC3)nn12

InChI Key: InChIKey=MKSNEZJPGYOXLT-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50258853   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50258853
PNG
(CHEMBL468940 | N-cyclopropyl-3-(3-(trifluoromethyl...)
Show SMILES FC(F)(F)c1cccc(c1)-c1nnc2ccc(NC3CC3)nn12
Show InChI InChI=1S/C15H12F3N5/c16-15(17,18)10-3-1-2-9(8-10)14-21-20-13-7-6-12(22-23(13)14)19-11-4-5-11/h1-3,6-8,11H,4-5H2,(H,19,22)
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Article
PubMed
18n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...


Bioorg Med Chem Lett 19: 3019-22 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.061
BindingDB Entry DOI: 10.7270/Q21J99PJ
More data for this
Ligand-Target Pair