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BDBM50258857 CHEMBL512095::N-cyclopropyl-3-(3-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-amine

SMILES: COc1cccc(c1)-c1nnc2ccc(NC3CC3)nn12

InChI Key: InChIKey=LKLBREDJNPZXBM-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50258857   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50258857
PNG
(CHEMBL512095 | N-cyclopropyl-3-(3-methoxyphenyl)-[...)
Show SMILES COc1cccc(c1)-c1nnc2ccc(NC3CC3)nn12
Show InChI InChI=1S/C15H15N5O/c1-21-12-4-2-3-10(9-12)15-18-17-14-8-7-13(19-20(14)15)16-11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,16,19)
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KEGG

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PC cid
PC sid
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Patents

Article
PubMed
410n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...


Bioorg Med Chem Lett 19: 3019-22 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.061
BindingDB Entry DOI: 10.7270/Q21J99PJ
More data for this
Ligand-Target Pair