BDBM50259107 3-isopropyl-5-(((1S, 2R)-2-(6-methylpyridazin-3-ylamino)cyclohexyl)methyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one::CHEMBL513304

SMILES: CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ccc(C)nn1)[nH]c2=O

InChI Key: InChIKey=PMRWYXIODMVINY-UONOGXRCSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50259107   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM50259107 (3-isopropyl-5-(((1S, 2R)-2-(6-methylpyridazin-3-yl...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ccc(C)nn1)[nH]c2=O |r| Show InChI InChI=1S/C20H27N7O/c1-11(2)17-18-19(27-26-17)20(28)23-16(22-18)10-13-6-4-5-7-14(13)21-15-9-8-12(3)24-25-15/h8-9,11,13-14H,4-7,10H2,1-3H3,(H,21,25)(H,26,27)(H,22,23,28)/t13-,14+/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM50259107 (3-isopropyl-5-(((1S, 2R)-2-(6-methylpyridazin-3-yl...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ccc(C)nn1)[nH]c2=O |r| Show InChI InChI=1S/C20H27N7O/c1-11(2)17-18-19(27-26-17)20(28)23-16(22-18)10-13-6-4-5-7-14(13)21-15-9-8-12(3)24-25-15/h8-9,11,13-14H,4-7,10H2,1-3H3,(H,21,25)(H,26,27)(H,22,23,28)/t13-,14+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM50259107 (3-isopropyl-5-(((1S, 2R)-2-(6-methylpyridazin-3-yl...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ccc(C)nn1)[nH]c2=O |r| Show InChI InChI=1S/C20H27N7O/c1-11(2)17-18-19(27-26-17)20(28)23-16(22-18)10-13-6-4-5-7-14(13)21-15-9-8-12(3)24-25-15/h8-9,11,13-14H,4-7,10H2,1-3H3,(H,21,25)(H,26,27)(H,22,23,28)/t13-,14+/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair