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BDBM50259137 7-(2-chlorophenyl)-6-(4-chlorophenyl)-2-methylpyrido[2,3-d]pyrimidin-4-ol::CHEMBL466063

SMILES: Cc1nc2nc(-c3ccccc3Cl)c(cc2c(=O)[nH]1)-c1ccc(Cl)cc1

InChI Key: InChIKey=OWFZUYXZECRMQJ-UHFFFAOYSA-N

Data: 2 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50259137   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50259137
PNG
(7-(2-chlorophenyl)-6-(4-chlorophenyl)-2-methylpyri...)
Show SMILES Cc1nc2nc(-c3ccccc3Cl)c(cc2c(=O)[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H13Cl2N3O/c1-11-23-19-16(20(26)24-11)10-15(12-6-8-13(21)9-7-12)18(25-19)14-4-2-3-5-17(14)22/h2-10H,1H3,(H,23,24,25,26)
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human cannabinoid CB2R expressed in CHO cells


Bioorg Med Chem Lett 19: 2591-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.005
BindingDB Entry DOI: 10.7270/Q2PK0G1X
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50259137
PNG
(7-(2-chlorophenyl)-6-(4-chlorophenyl)-2-methylpyri...)
Show SMILES Cc1nc2nc(-c3ccccc3Cl)c(cc2c(=O)[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H13Cl2N3O/c1-11-23-19-16(20(26)24-11)10-15(12-6-8-13(21)9-7-12)18(25-19)14-4-2-3-5-17(14)22/h2-10H,1H3,(H,23,24,25,26)
PDB

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UniProtKB/SwissProt

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antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulation


Bioorg Med Chem Lett 19: 2591-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.005
BindingDB Entry DOI: 10.7270/Q2PK0G1X
More data for this
Ligand-Target Pair