BDBM50259249 CHEMBL4095224
SMILES: Clc1ccc(cc1)C(NC(=O)OCCCc1c[nH]cn1)c1ccc(Cl)cc1
InChI Key: InChIKey=UYMBIBLZLAJMQD-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50259249 (CHEMBL4095224) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech Curated by ChEMBL | Assay Description Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta s... | Eur J Med Chem 125: 565-572 (2017) Article DOI: 10.1016/j.ejmech.2016.09.074 BindingDB Entry DOI: 10.7270/Q20C4Z66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine receptor (H3 and H4) (Homo sapiens (Human)) | BDBM50259249 (CHEMBL4095224) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech Curated by ChEMBL | Assay Description Antagonist activity at H4 receptor in human SH-SY5Y cells assessed as inhibition of imetit-induced GTPgamma[35S] binding after 30 mins by microbeta s... | Eur J Med Chem 125: 565-572 (2017) Article DOI: 10.1016/j.ejmech.2016.09.074 BindingDB Entry DOI: 10.7270/Q20C4Z66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50259249 (CHEMBL4095224) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 258 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bioprojet-Biotech Curated by ChEMBL | Assay Description Antagonist activity at H3 receptor (unknown origin) | Eur J Med Chem 125: 565-572 (2017) Article DOI: 10.1016/j.ejmech.2016.09.074 BindingDB Entry DOI: 10.7270/Q20C4Z66 | |||||||||||
More data for this Ligand-Target Pair |