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BDBM50259348 CHEMBL3084547::endo-8-(bis(2-chlorophenyl)methyl)-3-(pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-amine

SMILES: [H][C@]12CC[C@]([H])(C[C@@](N)(C1)c1ccccn1)N2C(c1ccccc1Cl)c1ccccc1Cl

InChI Key: InChIKey=XLSZJRCCIPFELW-QZTJIDSGSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50259348   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (Human))
BDBM50259348
PNG
(CHEMBL3084547 | endo-8-(bis(2-chlorophenyl)methyl)...)
Show SMILES [H][C@]12CC[C@]([H])(C[C@@](N)(C1)c1ccccn1)N2C(c1ccccc1Cl)c1ccccc1Cl |r,TLB:8:7:16:3.2|
Show InChI InChI=1S/C25H25Cl2N3/c26-21-9-3-1-7-19(21)24(20-8-2-4-10-22(20)27)30-17-12-13-18(30)16-25(28,15-17)23-11-5-6-14-29-23/h1-11,14,17-18,24H,12-13,15-16,28H2/t17-,18-/m1/s1
PDB

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
10n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I][Tyr14]nociceptin from human cloned ORL1 receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 2482-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.057
BindingDB Entry DOI: 10.7270/Q2D21XH9
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50259348
PNG
(CHEMBL3084547 | endo-8-(bis(2-chlorophenyl)methyl)...)
Show SMILES [H][C@]12CC[C@]([H])(C[C@@](N)(C1)c1ccccn1)N2C(c1ccccc1Cl)c1ccccc1Cl |r,TLB:8:7:16:3.2|
Show InChI InChI=1S/C25H25Cl2N3/c26-21-9-3-1-7-19(21)24(20-8-2-4-10-22(20)27)30-17-12-13-18(30)16-25(28,15-17)23-11-5-6-14-29-23/h1-11,14,17-18,24H,12-13,15-16,28H2/t17-,18-/m1/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
343n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 2482-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.057
BindingDB Entry DOI: 10.7270/Q2D21XH9
More data for this
Ligand-Target Pair