BDBM50259397 CHEMBL3084549::endo-N-(8-(bis(2-chlorophenyl)methyl)-3-(pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)acetamide

SMILES: [H][C@]12CC[C@]([H])(C[C@](C1)(NC(C)=O)c1ccccn1)N2C(c1ccccc1Cl)c1ccccc1Cl

InChI Key: InChIKey=VQBNHSQWESCIPZ-WOJBJXKFSA-N

Data: 2 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50259397   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50259397 (CHEMBL3084549 | endo-N-(8-(bis(2-chlorophenyl)meth...) Show SMILES [H][C@]12CC[C@]([H])(C[C@](C1)(NC(C)=O)c1ccccn1)N2C(c1ccccc1Cl)c1ccccc1Cl |r,TLB:9:7:19:3.2| Show InChI InChI=1S/C27H27Cl2N3O/c1-18(33)31-27(25-12-6-7-15-30-25)16-19-13-14-20(17-27)32(19)26(21-8-2-4-10-23(21)28)22-9-3-5-11-24(22)29/h2-12,15,19-20,26H,13-14,16-17H2,1H3,(H,31,33)/t19-,20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [125I][Tyr14]nociceptin from human cloned ORL1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 2482-6 (2009) Article DOI: 10.1016/j.bmcl.2009.03.057 BindingDB Entry DOI: 10.7270/Q2D21XH9
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50259397 (CHEMBL3084549 | endo-N-(8-(bis(2-chlorophenyl)meth...) Show SMILES [H][C@]12CC[C@]([H])(C[C@](C1)(NC(C)=O)c1ccccn1)N2C(c1ccccc1Cl)c1ccccc1Cl |r,TLB:9:7:19:3.2| Show InChI InChI=1S/C27H27Cl2N3O/c1-18(33)31-27(25-12-6-7-15-30-25)16-19-13-14-20(17-27)32(19)26(21-8-2-4-10-23(21)28)22-9-3-5-11-24(22)29/h2-12,15,19-20,26H,13-14,16-17H2,1H3,(H,31,33)/t19-,20-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	312	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 2482-6 (2009) Article DOI: 10.1016/j.bmcl.2009.03.057 BindingDB Entry DOI: 10.7270/Q2D21XH9
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50259397 (CHEMBL3084549 | endo-N-(8-(bis(2-chlorophenyl)meth...) Show SMILES [H][C@]12CC[C@]([H])(C[C@](C1)(NC(C)=O)c1ccccn1)N2C(c1ccccc1Cl)c1ccccc1Cl |r,TLB:9:7:19:3.2| Show InChI InChI=1S/C27H27Cl2N3O/c1-18(33)31-27(25-12-6-7-15-30-25)16-19-13-14-20(17-27)32(19)26(21-8-2-4-10-23(21)28)22-9-3-5-11-24(22)29/h2-12,15,19-20,26H,13-14,16-17H2,1H3,(H,31,33)/t19-,20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Agonist activity at human cloned ORL1 receptor assessed as stimulation of GTPgammaS binding				Bioorg Med Chem Lett 19: 2482-6 (2009) Article DOI: 10.1016/j.bmcl.2009.03.057 BindingDB Entry DOI: 10.7270/Q2D21XH9
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50259397 (CHEMBL3084549 | endo-N-(8-(bis(2-chlorophenyl)meth...) Show SMILES [H][C@]12CC[C@]([H])(C[C@](C1)(NC(C)=O)c1ccccn1)N2C(c1ccccc1Cl)c1ccccc1Cl |r,TLB:9:7:19:3.2| Show InChI InChI=1S/C27H27Cl2N3O/c1-18(33)31-27(25-12-6-7-15-30-25)16-19-13-14-20(17-27)32(19)26(21-8-2-4-10-23(21)28)22-9-3-5-11-24(22)29/h2-12,15,19-20,26H,13-14,16-17H2,1H3,(H,31,33)/t19-,20-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.93E+3	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Agonist activity at human mu opioid assessed as stimulation of GTPgammaS binding				Bioorg Med Chem Lett 19: 2482-6 (2009) Article DOI: 10.1016/j.bmcl.2009.03.057 BindingDB Entry DOI: 10.7270/Q2D21XH9
					More data for this Ligand-Target Pair