null

SMILES: Clc1ccc2c(NC3=NCC4(CN5CCC4CC5)N3)ncnn12

InChI Key: InChIKey=OYEJQWOXIANAAQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50259923   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50259923 (CHEMBL4078355) Show SMILES Clc1ccc2c(NC3=NCC4(CN5CCC4CC5)N3)ncnn12 |t:7,THB:18:10:13.14:16.17,(37.59,-16.14,;36.12,-15.66,;34.88,-16.57,;33.64,-15.66,;34.11,-14.2,;33.35,-12.86,;31.81,-12.86,;31.04,-14.19,;31.66,-15.6,;30.51,-16.63,;29.18,-15.86,;28.97,-17.24,;27.05,-16.44,;25.65,-17.37,;26,-15.97,;27.7,-15.21,;27.63,-13.57,;27.05,-14.97,;29.5,-14.35,;34.11,-11.52,;35.66,-11.53,;36.43,-12.87,;35.65,-14.2,)| Show InChI InChI=1S/C15H18ClN7/c16-12-2-1-11-13(18-9-19-23(11)12)20-14-17-7-15(21-14)8-22-5-3-10(15)4-6-22/h1-2,9-10H,3-8H2,(H2,17,18,19,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	62	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Agonist activity at alpha7 nAChR (unknown origin) expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based FLIPR assay				Bioorg Med Chem Lett 27: 578-581 (2017) Article DOI: 10.1016/j.bmcl.2016.12.014 BindingDB Entry DOI: 10.7270/Q28P62ZN
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50259923 (CHEMBL4078355) Show SMILES Clc1ccc2c(NC3=NCC4(CN5CCC4CC5)N3)ncnn12 |t:7,THB:18:10:13.14:16.17,(37.59,-16.14,;36.12,-15.66,;34.88,-16.57,;33.64,-15.66,;34.11,-14.2,;33.35,-12.86,;31.81,-12.86,;31.04,-14.19,;31.66,-15.6,;30.51,-16.63,;29.18,-15.86,;28.97,-17.24,;27.05,-16.44,;25.65,-17.37,;26,-15.97,;27.7,-15.21,;27.63,-13.57,;27.05,-14.97,;29.5,-14.35,;34.11,-11.52,;35.66,-11.53,;36.43,-12.87,;35.65,-14.2,)| Show InChI InChI=1S/C15H18ClN7/c16-12-2-1-11-13(18-9-19-23(11)12)20-14-17-7-15(21-14)8-22-5-3-10(15)4-6-22/h1-2,9-10H,3-8H2,(H2,17,18,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assay				Bioorg Med Chem Lett 27: 578-581 (2017) Article DOI: 10.1016/j.bmcl.2016.12.014 BindingDB Entry DOI: 10.7270/Q28P62ZN
					More data for this Ligand-Target Pair