BDBM50260184 CHEMBL4068733

SMILES: COc1cccc(Nc2ncc3CN(C(=O)N(C4CCN(CC4)C(=O)\C=C\CN(C)C)c3n2)c2c(Cl)c(OC)cc(OC)c2Cl)c1

InChI Key: InChIKey=MKEGPZIMUWZUKO-JXMROGBWSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50260184   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50260184 (CHEMBL4068733) Show SMILES COc1cccc(Nc2ncc3CN(C(=O)N(C4CCN(CC4)C(=O)\C=C\CN(C)C)c3n2)c2c(Cl)c(OC)cc(OC)c2Cl)c1 Show InChI InChI=1S/C32H37Cl2N7O5/c1-38(2)13-7-10-26(42)39-14-11-22(12-15-39)41-30-20(18-35-31(37-30)36-21-8-6-9-23(16-21)44-3)19-40(32(41)43)29-27(33)24(45-4)17-25(46-5)28(29)34/h6-10,16-18,22H,11-15,19H2,1-5H3,(H,35,36,37)/b10-7+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Guangzhou Institutes of Biomedicine and Health Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged FGFR4 cytoplasmic domain (781 to 1338 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by...				Eur J Med Chem 135: 531-543 (2017) Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50260184 (CHEMBL4068733) Show SMILES COc1cccc(Nc2ncc3CN(C(=O)N(C4CCN(CC4)C(=O)\C=C\CN(C)C)c3n2)c2c(Cl)c(OC)cc(OC)c2Cl)c1 Show InChI InChI=1S/C32H37Cl2N7O5/c1-38(2)13-7-10-26(42)39-14-11-22(12-15-39)41-30-20(18-35-31(37-30)36-21-8-6-9-23(16-21)44-3)19-40(32(41)43)29-27(33)24(45-4)17-25(46-5)28(29)34/h6-10,16-18,22H,11-15,19H2,1-5H3,(H,35,36,37)/b10-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Guangzhou Institutes of Biomedicine and Health Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...				Eur J Med Chem 135: 531-543 (2017) Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM50260184 (CHEMBL4068733) Show SMILES COc1cccc(Nc2ncc3CN(C(=O)N(C4CCN(CC4)C(=O)\C=C\CN(C)C)c3n2)c2c(Cl)c(OC)cc(OC)c2Cl)c1 Show InChI InChI=1S/C32H37Cl2N7O5/c1-38(2)13-7-10-26(42)39-14-11-22(12-15-39)41-30-20(18-35-31(37-30)36-21-8-6-9-23(16-21)44-3)19-40(32(41)43)29-27(33)24(45-4)17-25(46-5)28(29)34/h6-10,16-18,22H,11-15,19H2,1-5H3,(H,35,36,37)/b10-7+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
Guangzhou Institutes of Biomedicine and Health Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged FGFR3 cytoplasmic domain (399 to 806 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...				Eur J Med Chem 135: 531-543 (2017) Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50260184 (CHEMBL4068733) Show SMILES COc1cccc(Nc2ncc3CN(C(=O)N(C4CCN(CC4)C(=O)\C=C\CN(C)C)c3n2)c2c(Cl)c(OC)cc(OC)c2Cl)c1 Show InChI InChI=1S/C32H37Cl2N7O5/c1-38(2)13-7-10-26(42)39-14-11-22(12-15-39)41-30-20(18-35-31(37-30)36-21-8-6-9-23(16-21)44-3)19-40(32(41)43)29-27(33)24(45-4)17-25(46-5)28(29)34/h6-10,16-18,22H,11-15,19H2,1-5H3,(H,35,36,37)/b10-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Guangzhou Institutes of Biomedicine and Health Curated by ChEMBL					Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...				Eur J Med Chem 135: 531-543 (2017) Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF
					More data for this Ligand-Target Pair