BDBM50260890 3-(2-aminoquinazolin-6-yl)-1-(4-tert-butylphenyl)-4-methylpyridin-2(1H)-one::CHEMBL496494

SMILES: Cc1ccn(-c2ccc(cc2)C(C)(C)C)c(=O)c1-c1ccc2nc(N)ncc2c1

InChI Key: InChIKey=OLGFKJJJBLWTNP-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50260890   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50260890 (3-(2-aminoquinazolin-6-yl)-1-(4-tert-butylphenyl)-...) Show SMILES Cc1ccn(-c2ccc(cc2)C(C)(C)C)c(=O)c1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C24H24N4O/c1-15-11-12-28(19-8-6-18(7-9-19)24(2,3)4)22(29)21(15)16-5-10-20-17(13-16)14-26-23(25)27-20/h5-14H,1-4H3,(H2,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of c-Kit (unknown origin) by TR-FRET assay				J Med Chem 51: 3065-8 (2008) Article DOI: 10.1021/jm800188g BindingDB Entry DOI: 10.7270/Q2DN44TT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50260890 (3-(2-aminoquinazolin-6-yl)-1-(4-tert-butylphenyl)-...) Show SMILES Cc1ccn(-c2ccc(cc2)C(C)(C)C)c(=O)c1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C24H24N4O/c1-15-11-12-28(19-8-6-18(7-9-19)24(2,3)4)22(29)21(15)16-5-10-20-17(13-16)14-26-23(25)27-20/h5-14H,1-4H3,(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of KDR (unknown origin) by TR-FRET assay				J Med Chem 51: 3065-8 (2008) Article DOI: 10.1021/jm800188g BindingDB Entry DOI: 10.7270/Q2DN44TT
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50260890 (3-(2-aminoquinazolin-6-yl)-1-(4-tert-butylphenyl)-...) Show SMILES Cc1ccn(-c2ccc(cc2)C(C)(C)C)c(=O)c1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C24H24N4O/c1-15-11-12-28(19-8-6-18(7-9-19)24(2,3)4)22(29)21(15)16-5-10-20-17(13-16)14-26-23(25)27-20/h5-14H,1-4H3,(H2,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of SCF-induced phosphorylation of c-Kit (unknown origin) in MO7e cells by TR-FRET assay				J Med Chem 51: 3065-8 (2008) Article DOI: 10.1021/jm800188g BindingDB Entry DOI: 10.7270/Q2DN44TT
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50260890 (3-(2-aminoquinazolin-6-yl)-1-(4-tert-butylphenyl)-...) Show SMILES Cc1ccn(-c2ccc(cc2)C(C)(C)C)c(=O)c1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C24H24N4O/c1-15-11-12-28(19-8-6-18(7-9-19)24(2,3)4)22(29)21(15)16-5-10-20-17(13-16)14-26-23(25)27-20/h5-14H,1-4H3,(H2,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of Src (unknown origin) by TR-FRET assay				J Med Chem 51: 3065-8 (2008) Article DOI: 10.1021/jm800188g BindingDB Entry DOI: 10.7270/Q2DN44TT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50260890 (3-(2-aminoquinazolin-6-yl)-1-(4-tert-butylphenyl)-...) Show SMILES Cc1ccn(-c2ccc(cc2)C(C)(C)C)c(=O)c1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C24H24N4O/c1-15-11-12-28(19-8-6-18(7-9-19)24(2,3)4)22(29)21(15)16-5-10-20-17(13-16)14-26-23(25)27-20/h5-14H,1-4H3,(H2,25,26,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of Lck (unknown origin) by TR-FRET assay				J Med Chem 51: 3065-8 (2008) Article DOI: 10.1021/jm800188g BindingDB Entry DOI: 10.7270/Q2DN44TT
					More data for this Ligand-Target Pair