BDBM50261207 6-((R)-2-amino-2-phenylethyl)-3,8-bis(2-fluorophenyl)-2,3-dihydro-6H-thiazolo[3,2-f]pyrimidine-5,7-dione::CHEMBL523709

SMILES: N[C@@H](Cn1c(=O)c(c2SCC(c3ccccc3F)n2c1=O)-c1ccccc1F)c1ccccc1

InChI Key: InChIKey=WVAOLSBXBIROBU-HMTLIYDFSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50261207   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50261207 (6-((R)-2-amino-2-phenylethyl)-3,8-bis(2-fluorophen...) Show SMILES N[C@@H](Cn1c(=O)c(c2SCC(c3ccccc3F)n2c1=O)-c1ccccc1F)c1ccccc1 |r,wD:1.0,(22.56,.15,;22.55,1.69,;23.89,2.46,;25.22,1.7,;26.55,2.47,;26.55,4.01,;27.88,1.7,;27.88,.16,;29.02,-.86,;28.4,-2.26,;26.88,-2.1,;25.86,-3.24,;24.35,-2.92,;23.32,-4.07,;23.8,-5.54,;25.32,-5.85,;26.34,-4.7,;27.85,-5.01,;26.56,-.61,;25.22,.16,;23.89,-.62,;29.21,2.47,;30.54,1.7,;31.88,2.47,;31.88,4.01,;30.53,4.78,;29.2,4,;27.86,4.76,;21.22,2.45,;21.22,3.99,;19.89,4.76,;18.55,3.98,;18.56,2.44,;19.9,1.68,)| Show InChI InChI=1S/C26H21F2N3O2S/c27-19-12-6-4-10-17(19)22-15-34-25-23(18-11-5-7-13-20(18)28)24(32)30(26(33)31(22)25)14-21(29)16-8-2-1-3-9-16/h1-13,21-22H,14-15,29H2/t21-,22?/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc Curated by ChEMBL					Assay Description Binding affinity at human GnRH receptor				J Med Chem 51: 3331-48 (2008) Article DOI: 10.1021/jm701249f BindingDB Entry DOI: 10.7270/Q2KD1XQ0
					More data for this Ligand-Target Pair