BDBM50261263 3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one::CHEMBL513151

SMILES: Nc1cc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F

InChI Key: InChIKey=QBTWRBDYIMWDCX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50261263   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vanilloid receptor (Rattus norvegicus (rat))	BDBM50261263 (3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)py...) Show SMILES Nc1cc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C19H13F3N6O2/c20-19(21,22)9-4-5-10(11(23)6-9)13-7-15(26-8-25-13)30-14-3-1-2-12-16(14)28-17(24)18(29)27-12/h1-8H,23H2,(H2,24,28)(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Vanilloid receptor (Rattus norvegicus (rat))	BDBM50261263 (3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)py...) Show SMILES Nc1cc(ccc1-c1cc(Oc2cccc3[nH]c(=O)c(N)nc23)ncn1)C(F)(F)F Show InChI InChI=1S/C19H13F3N6O2/c20-19(21,22)9-4-5-10(11(23)6-9)13-7-15(26-8-25-13)30-14-3-1-2-12-16(14)28-17(24)18(29)27-12/h1-8H,23H2,(H2,24,28)(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair