BDBM50261316 3-Amino-5-(6-(2-(2-morpholinoethylamino)-6-(trifluoromethyl)pyridin-3-yl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one::CHEMBL511393

SMILES: Nc1nc2c(Oc3cc(ncn3)-c3ccc(nc3NCCN3CCOCC3)C(F)(F)F)cccc2[nH]c1=O

InChI Key: InChIKey=OHJXUHGHYSMZRL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50261316   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vanilloid receptor (Rattus norvegicus (rat))	BDBM50261316 (3-Amino-5-(6-(2-(2-morpholinoethylamino)-6-(triflu...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(nc3NCCN3CCOCC3)C(F)(F)F)cccc2[nH]c1=O Show InChI InChI=1S/C24H23F3N8O3/c25-24(26,27)18-5-4-14(22(33-18)29-6-7-35-8-10-37-11-9-35)16-12-19(31-13-30-16)38-17-3-1-2-15-20(17)34-21(28)23(36)32-15/h1-5,12-13H,6-11H2,(H2,28,34)(H,29,33)(H,32,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair
Vanilloid receptor (Rattus norvegicus (rat))	BDBM50261316 (3-Amino-5-(6-(2-(2-morpholinoethylamino)-6-(triflu...) Show SMILES Nc1nc2c(Oc3cc(ncn3)-c3ccc(nc3NCCN3CCOCC3)C(F)(F)F)cccc2[nH]c1=O Show InChI InChI=1S/C24H23F3N8O3/c25-24(26,27)18-5-4-14(22(33-18)29-6-7-35-8-10-37-11-9-35)16-12-19(31-13-30-16)38-17-3-1-2-15-20(17)34-21(28)23(36)32-15/h1-5,12-13H,6-11H2,(H2,28,34)(H,29,33)(H,32,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	5.0	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influx				J Med Chem 51: 2744-57 (2008) Article DOI: 10.1021/jm7014638 BindingDB Entry DOI: 10.7270/Q2930SZH
					More data for this Ligand-Target Pair